As GLP-1 weight loss drugs become well-known, the term Ozempic face has started popping up in media and conversations. Is Ozempic face something you should be concerned about if you are considering starting semaglutide or other weight loss medication?
Learn more about the signs, prevention options and treatments for Ozempic face in this comprehensive guide.
What is Ozempic face?
The term “Ozempic face” is a cultural saying that has emerged to describe certain facial features of individuals who have lost weight on the diabetic drug, semaglutide (Ozempic®). It is not a recognized medical condition.
Characteristics of Ozempic face often include loose or sagging skin, hallowed-out features and the appearance of aging.
Ozempic and other GLP-1 weight loss medications do not target fat loss in the face. Rapid weight loss, from medication or otherwise, can naturally cause changes in facial features, but it is not caused by Ozempic.
Experts have warned against using this term, as it is derogatory and misleading.1
What does Ozempic face look like?

Ozempic face is characterized by signs of facial fat loss, including:2
Sunken eyes or dark circles under the eyes.
Hollowed cheekbones or temples.
Increased wrinkles around the eyes, forehead and mouth.
Sagging skin around the jawline and jowls.
Does everyone get Ozempic face?
Most people who take semaglutide or other GLP-1 medications like tirzepatide will not end up with Ozempic face, although the face may appear slimmer due to weight loss.
The signs attributed to Ozempic face can occur on anyone who has experienced rapid weight loss.3
Can Ozempic face go away on its own?
The signs of the Ozempic face may be reduced if the weight stabilizes. Otherwise, treatment is usually required to reduce wrinkles, skin elasticity and other facial features.4
Is Ozempic face permanent?
Many signs of Ozempic face can be reduced or eliminated with treatments. There are skin care, fillers, hydration and surgical interventions to treat wrinkles, sagging skin, or hallowed features. In some cases, the signs of Ozempic face cannot be reversed, just like with signs of aging.5
How do you treat Ozempic face?
There are three main causes of Ozempic face: facial fat loss, reduced skin elasticity and rapid fat loss. It can lead to symptoms similar to signs of aging like wrinkles and sagging.6 These can be treated with cosmetic procedures, including:7
Derma fillers.
Plastic or cosmetic surgery.
Microneedling.
Platelet-rich plasma (PRP) injections.
Can Ozempic face go away on its own?
The signs of the Ozempic face may be reduced if the weight stabilizes. Otherwise, treatment is usually required to reduce wrinkles, skin elasticity and other facial features.4
Is Ozempic face permanent?
Many signs of Ozempic face can be reduced or eliminated with treatments. There are skin care, fillers, hydration and surgical interventions to treat wrinkles, sagging skin, or hallowed features. In some cases, the signs of Ozempic face cannot be reversed, just like with signs of aging.5

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Get StartedHow do you treat Ozempic face?
There are three main causes of Ozempic face: facial fat loss, reduced skin elasticity and rapid fat loss. It can lead to symptoms similar to signs of aging like wrinkles and sagging.6 These can be treated with cosmetic procedures, including:7
Derma fillers.
Plastic or cosmetic surgery.
Microneedling.
Platelet-rich plasma (PRP) injections.
Can you avoid Ozempic face?

There is no way to avoid Ozempic face after weight loss completely, but you can minimize the signs with some preventative measures. Ways to help prevent Ozempic face include:8
Lose weight slowly and gradually. Rapid weight loss contributes to the Ozempic face. If you are losing weight too fast, talk to your provider about changing your medication dosage.
Stay hydrated. Dry skin can increase the formation of wrinkles and fine lines.9 Drinking plenty of water can improve skin’s elasticity as well.10
Proper skin care routine. Topical moisturizers and collagen-boosting products can help reduce the appearance of wrinkles.
Prescription skin care. Medicated skin care products can help reduce and prevent the signs of aging common to the Ozempic face. Retinoids, like tretinoin (Retin-A®) and tazarotene (Tazorac®), are the most popular and clinically studied prescription skin care products.11
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