Premature ejaculation (PE)1 is the most common type of sexual dysfunction in men. It affects as many as 30% to 40% of all men at some point in their life. It can have a wide range of causes, from hypersensitivity to medical conditions to psychological factors.The critical thing to remember when treating PE is that you are not alone. The condition is very common, even if it is not openly discussed, and is easily treatable.
What are common premature ejaculation medications?
Premature ejaculation treatments are available in two main types: topical and oral medications. Topical treatments are applied directly to the genitals to reduce sensation and delay ejaculation. Topical treatments for PE include:
Desensitizing cream or spray
Benzocaine wipes
Oral medications can help men maintain an erection or delay climax. Oral medications often have cross-over uses, like antidepressants or erectile dysfunction medication. Oral medication types for premature ejaculation include:
SSRIs
PDE5 Inhibitors
Topical Treatments for Premature Ejaculation
Topical treatments are applied directly to the genitals anywhere from five to 20 minutes before intercourse to reduce sensation and have been shown to delay orgasm in men by three to six minutes.2 However, for some users, topical treatments can cause loss of sexual desire or erectile disruption due to numbness.3
One risk of using topical treatments for PE is that the numbing ingredients can transfer to your partner, reducing sensation for them as well. Using a condom can mitigate the transfer of topical treatment to your partner during sexual contact.
Lidocaine (4%) Cream for PE
Lidocaine cream is a topical PE medication that numbs the application area with local anesthetics. When applied to male genitals, desensitization helps prolong an erection and prevent premature ejaculation.
Lidocaine is available via a prescription or over-the-counter.
Benzocaine Wipes for PE
Benzocaine is a mild anesthetic that is widely available in over-the-counter pain relief products. When used topically on the skin, it can create numbness and desensitizes the area.
Benzocaine wipes4 have been developed specifically for PE as a convenient method to apply anesthetic to the genitals. It has shown some promise in small studies to help men with PE last longer during intercourse.
Benzocaine wipes for PE are available over the counter.
SSRIs for Premature Ejaculation
Selective serotonin reuptake inhibitors, or SSRIs are medications generally prescribed for mental health conditions like depression and anxiety. One of the side effects of SSRIs is delayed ejaculation, and has been shown in studies5 to improve symptoms of PE in men significantly. For that reason, medical providers often prescribe SSRIs for off-label use to treat PE.
Sertraline (Zoloft®) for PE
Sertraline (generic Zoloft) is part of the classification of drugs called SSRIs. It is used for the treatment of a wide range of conditions, including depression, anxiety, OCD, PTSD, and PMS.6
Is it unknown exactly how sertraline for PE works, but it has shown positive results in studies.7 A prescription is required for sertraline.
Paroxetine (Paxil®) for PE
Paroxetine (generic Paxil) is another SSRI that has shown promising study results for treating PE.8 Although it is difficult to prove, some researchers believe that SSRIs ability to reduce depression and anxiety could be the foundation for treating PE. PE is a condition that can be wholly psychological rather than fully biological.
Paroxetine for PE is available by prescription only.
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PDE5 inhibitors are a classification of medications traditionally prescribed for erectile dysfunction. However, research has shown that PDE5 inhibitors can have positive results when prescribed for premature ejaculation as well. The best result for treating premature ejaculation is a combination of a PDE5 inhibitor and an SSRI, according to research.9
Sildenafil (Viagra®) for PE
Sildenafil (generic Viagra) is a commonly prescribed medication to treat erectile dysfunction. Studies10 have shown that sildenafil also has benefits for men that experience PE. In addition to helping delay ejaculation during vaginal intercourse, study participants reported an increase in sexual confidence, satisfaction, and a decrease in refractory time to achieve a second erection after ejaculation.11
A prescription is required to purchase sildenafil for PE.
Tadalafil (Cialis®) for PE
Tadalafil (generic Cialis) is also commonly prescribed for erectile dysfunction. Tadalafil can help treat PE, especially if symptoms for PE and ED are both present. Studies have shown using tadalafil for PE can prolong the ejaculatory latency time.12
A prescription is required to purchase tadalafil for PE.
PE Medication Comparison Chart
How RedBox Rx can help
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