Signs and symptoms of depression can vary among individuals, but some of the common signs include:¹

• Feelings of sadness, emptiness or hopelessness

• Irritability and angry outbursts

• Insomnia or sleeping too much

• Fatigue

• Slowed movement, including speaking and body movements

• Changes in appetite

• Brain fog and difficulty making decisions

• Suicidal thoughts and thoughts of self-harm

• Unexplained physical problems like back pain or headaches

Depression is a complex condition that varies among individuals. There are a few risk factors known to trigger or contribute to depression, including:²

• Abuse

• Trauma

• Grief

• Genetics

• Illness

• Substance abuse

• Certain medications

• Major life changes (good or bad)

Best results for treating depression are based on the individual and often require multiple forms of treatment. The main categories of treatment fall under therapy, lifestyle changes and medication.³ Start an online consult with RedBox Rx to discuss your medication treatment options.

Yes, you can start an online consult with a licensed medical provider through RedBox Rx to discuss treatment options for depression.

1. Mayo Clinic

2. Cleveland Clinic

3. Mayo Clinic

There are five commonly prescribed classes of medications used to treat depression: selective serotonin reuptake inhibitors (SSRIs), serotonin norepinephrine reuptake inhibitors (SNRIs), norepinephrine and dopamine reuptake inhibitors (NDRIs), tricyclic antidepressants and monoamine oxidase inhibitors (MAOIs).

RedBox Rx prescribes the following types of depression medications:

• SSRIs block reuptake of serotonin, a mood regulating chemical, in the brain to create higher levels of the mood regulating chemical. Common SSRIs include:¹

• Citalopram (Celexa®)

• Paroxetine (Paxil®)

• Escitalopram (Lexapro®)

• Fluoxetine (Prozac®)

• Sertraline (Zoloft®)

• SNRIs block the reuptake of serotonin and norepinephrine to help balance chemicals in the brain and regulate mood. Common SNRIs include:²

• Duloxetine (Cymbalta®)

• Venlafaxine ER (Effexor XR®)

• Norepinephrine and dopamine reuptake inhibitors (NDRIs) block receptors in the brain to increase levels of mood boosting dopamine and norepinephrine. The only NDRI currently approved for depression is:³

• Bupropion (Wellbutrin XL®)

The following are additional kinds of depression medications that RedBox Rx does not prescribe at this time due to legal reasons or concerns about side effects:

• Tricyclic antidepressants are reuptake inhibitors of serotonin and norepinephrine as well. They block more receptors than SSRIs or SNRIs which can sometimes make them more effective but can also cause more severe side effects. Common tricyclic antidepressants include:⁴

• Amitriptyline (Elavil®)

• Amoxapine (Asendin®)

• Desipramine (Norpramin®)

• Doxepin (Sinequan®)

• Imipramine (Tofranil®)

• Nortriptyline (Pamelor®)

• Protriptyline (Vivactil®)

• Trimipramine (Surmontil®)

• Monoamine oxidase inhibitors (MAOIs) block an enzyme called monoamine oxidase from removing serotonin, norepinephrine and dopamine from the brain. These were the first anti-depressants developed, but they are not as commonly prescribed today because of dangerous side effects. Common MAOIs include:⁵

• Isocarboxazid (Marplan®)

• Phenelzine (Nardil®)

• Selegiline (Emsam®)

• Tranylcypromine (Parnate®)

The most common antidepressants are reuptake inhibitors, including SSRIs, SNRIs and NDRIs.⁶

Common SSRIs include:

• Citalopram (Celexa®)

• Escitalopram (Lexapro®)

• Fluoxetine (Prozac®)

• Paroxetine (Paxil®)

• Sertraline (Zoloft®)

Common SNRIs include:

• Duloxetine (Cymbalta®)

• Venlafaxine ER (Effexor XR®)

Common NDRIs include:

• Bupropion (Wellbutrin XL®)

No, antidepressant medications are only available with a prescription. You can, however, get convenient online treatment for depression with medications shipped to your door through RedBox Rx.

Antidepressant medication costs $25 per month with purchase of a three-month supply through RedBox Rx. We’re able to offer low prices because we purchase depression medications directly from manufacturers and ship from our pharmacy in Iowa.

Results vary among individuals for effectiveness of antidepressants. Generally, most users see results within four to six weeks.⁶

The antidepressants are working if you see a reduction in depression symptoms. If you do not see any reduction in symptoms after eight weeks of use, get back in touch with your medical professional to discuss alternatives.⁷

Common side effects of reuptake inhibitor antidepressants include:⁸

• Nausea

• Constipation

• Dizziness

• Headache

• Dry mouth

• Excessive sweating

• Insomnia

To prescribe antidepressants in the U.S., a prescriber must be a licensed medical doctor or nurse practitioner. RedBox Rx has U.S. licensed medical providers ready to help you find your ideal depression treatment.

Yes, you can get depression medication online (if prescribed) with telehealth options like RedBox Rx. Start an online consult now to talk with a U.S. licensed medical provider about depression treatment options.

Yes, treatment through RedBox Rx is HSA and FSA eligible.

1. Anxiety & Depression Association of America

2. Mayo Clinic

3. Mayo Clinic

4. National Library of Medicine

5. Mayo Clinic

6. Mayo Clinic

7. Medline Plus

8. Mayo Clinic